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They serve as the main regulators of stress detection, signal transduction, and adaptive responses, which involve activating the antioxidant enzyme system and stress response pathways

In OA cartilage tissues and IL-1stimulated chondrocyte models, iron accumulation, elevated levels of lipid peroxidation byproducts such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), and downregulation of the antioxidant enzyme GPX4 have been widely reported ( Ferroptosis-related alterations are not limited to cartilage

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Z Naturforsch C , 55: 361372, 2000