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Archives of Neurology, 63 (11), 1545-1550

[DOI] [PMC free article] [PubMed] [Google Scholar] 295

These dysregulations lead to the impaired activation of the small GTPase RAP1, which is critical for cytoskeletal dynamics

Peptides derived from Laminaria japonica promote apoptosis by increasing cleaved caspase-9 and caspase-3 levels and activating PARP, potentially through upstream apoptotic signal-regulating kinase 1 (ASK1) phosphorylation and subsequent p38 MAPK activation (107)