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Br J Psychiatry (2009) 195:40813

However, a clinical study reported that paclitaxel caused hypothyroidism in several patients, suggesting that paclitaxel can disrupt the hormonal balance (Mie, 2025)

In addition, exposure to heavy metals (e.g., iron, lead, mercury, cadmium, arsenic, and Mn) and metal-based nanoparticles increases the risk of PD through the neurotoxic accumulation of metals in the SNpc and by increasing oxidative stress-induced apoptosis (Milatovic et al., 2009