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Moreover, a percentage of patients ranging between 7 and 25%, depending on different dosage, experience adverse events upon PDE5i treatment [59, 60], sometimes manifesting as of moderate or severe entity, the most frequent of which comprise flushing, headache, dyspepsia, back pain, myalgia, dizziness, and rhinitis [10], although discontinuation rates owing to adverse events of PDE5i is generally relatively low, and comprised between 3 and 5% of patients [61]

[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Gilbard J.P., Farris R.L

Mahmoud YK, Ali AA, Abdelrazek HM, Aldayel TS, Abdel-Daim MM, El-Menyawy MAI (2021) Neurotoxic effect of fipronil in male Wistar rats: ameliorative effect of L-arginine and L-carnitine

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Synthesis predominately occurs in the liver, kidneys, and to a lesser extent, the pancreas