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Description

Treatment of PDAC with DON decreases uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) levels, which affects synthesis of the hyaluronan-rich extracellular matrix (ECM)

Spiller HA (2017) Rethinking mercury: the role of selenium in the pathophysiology of mercury toxicity

A study addressing why the IGF-1R pathway silencing through IGF-1R fusion protein IGF-Trap-induced IGF-1/2 bioavailability reduction, which was a promising anticancer strategy in vitro failed in nude mice xenotransplanted with the human triple negative breast cancer MDA-MB-231 cells, found that these cells developed resistance to IGF-targeted therapy by increasing the activation of another receptor tyrosine kinase, fibroblast growth factor receptor 1 (FGFR1) (75)