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Cell Death Dis 7 , e2208 (2016)

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Also, we found that the injection type of serotonergic agents (systemic or local), the doses of these drugs (dose-dependent effects), and up- or down-regulation of serotonergic receptors during training with various memory tasks are important issues that can be involved in the effects of serotonergic signaling on sleepwake cycle, memory function, and sleep deprivation-induced memory impairments