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Importantly, these phenotypes contrast with the non-inducible liver-specific Gclc KO mouse strain ( Gclc f/f Albumin-Cre), which develops liver failure and dies shortly after birth 30

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In vivo investigations evaluated the effects of the formulations

Microglia with depleted GSH have an exacerbated ROS/RNS production, elevated pro-inflammatory cytokine release, impaired phagocytic clearance, and increased neurotoxic output ( As discussed, the interplay between astrocytes and microglia via modulation of GSH activity implies that GSH is not only a cellular antioxidant, but an important mediator of cross-talk between resident CNS immune cells