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Arthritis Rheum 60:661668

The peptide simply does not have the conformational features required for growth hormone receptor recognition and activation

10.1016/j.cell.2015.04.042 Summary Keywords intervertebral disc, low back pain, MSC, regenerative medicine, microenvironment, niche, extracellular vesicles (EVs), disc progenitor cells Citation Wang H, Xu A, Hua W, Mao J, Zhang J, Ma X and Lu L (2025) Stem cell-based strategies for intervertebral disc regeneration in degenerative microenvironments: challenges and solutions

This specific sequence was identified through systematic research aimed at isolating the lipolytic (fat-breaking) properties of growth hormone while eliminating the growth-promoting, diabetogenic, and other potentially problematic effects associated with full-length hGH therapy