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Histology showed Dox-induced myocardial remodeling and inflammation, which were attenuated by all treatments, restoring cardiomyocyte occupancy, reducing extracellular matrix expansion, and decreasing inflammatory infiltrate

Course duration 48 weeks with a 2-week break

Ursini F, Maiorino M, Valente M, Ferri L, Gregolin C (1982) Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides

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On the one hand, butyric acid prevents the decreased expression of PPAR- in the liver, which promotes fatty acid uptake, increases insulin sensitivity (181), and decreases the expression of pro-inflammatory cytokine gene (IL-1 and TNF-) macrophage infiltration-specific markers F4/80, which leads to a significant reduction of F4/80+ cell infiltration and anti-inflammatory cytokines in the liver of mice (IL-4 and IL-10) and activation of hepatic Kupffer cells, thereby preventing liver injury and inflammation in NAFLD mice (182)