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While Nrf2 responds to oxidative stress directly, certain key nutrients can improve this effect, the exact source of these nutrients varies widely but dark green and leafy vegetables (think spinach, kale and broccoli, especially the seed extract), or reddy vegetables and spices (saffron, tumeric or paprika) are a particularly rich source

Silverman RA, Ito K

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The most drastic examples of genetic influences on ageing are progeria syndromes (HutchinsonGilford progeria, Werner Syndrome, and other laminopathies) 233 where patients die of myocardial infarction or stroke at an early age

Key differences are: Its important for both doctors and patients to know these guidelines