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Daneshmandi S, Cassel T, Lin P, Higashi RM, Wulf GM, Boussiotis VA, et al

In addition to obesity, Covarrubias and colleagues found that during aging senescent cells significantly accumulate in visceral white adipose tissue and inflammatory cytokines found in the supernatant from senescent cells, which are induced macrophages to proliferate and to express CD38, as a T cell activation marker [73]

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Their primary advantage lies in directly pinpointing a cause-and-effect link between MSU and particular cell types

Bailey JL, Zheng B, Hu Z, Price SR, Mitch WE (2006) Chronic kidney disease causes defects in signaling through the insulin receptor substrate/phosphatidylinositol 3-kinase/Akt pathway: implications for muscle atrophy