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Gastrointestinal issues : Conditions like celiac disease or Crohn's disease can impair B12 absorption in the gut

The addition of high dose niacin was intended to increase HDL ("good") cholesterol, reduce elevated triglycerides, and, most importantly, reduce the risk of heart attacks and stoke

Only the loci that exhibited statistically significant differences between the compared groups were chosen for further analysis

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For asymptomatic, borderline cases, 50 g low-dose daily oral CN-Cbl is licensed (NICE, 2022)