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Modulation of sensitivity to phospholipid oxidation and ferroptosis by tumor suppressors and oncogenes is mediated by changed expression or activities of proteins that exert different functions in lipid peroxidation including those regulating iron handling (transferrin receptor, NCOA4), enzymes synthesizing peroxidation-prone PUFA-phospholipids (ACSL4), antioxidant enzymes (GPX4) and proteins involved in production of antioxidant proteins (NRF2) or small antioxidant molecules (SLC7A11, FSP1)

Distinctively, it focuses on the synergistic interplay between inflammation regulation, gut microbiota modulation, and insulin sensitivity

Min Zhang C, D'Arcy JH, Jiang-ping H, Xing X: Green tea and the prevention of breast cancer: a case-control study in Southeast China

PubMed Central , Journal of Hepatology , vol

PNPLA2 has retinyl esterase activity, which is activated by ABHD5 in hepatic stellate cells (78)