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Additionally, HIF-1 supports the maintenance of GSCs by upregulating stemness-associated genes such as KLF4, MYC, OCT4, SOX2, and NANOG, sustaining their self-renewal and resistance to conventional therapies

These patients often require higher doses (350-450mcg) achieving similar results as metabolically healthy patients at lower doses

Exercise also modulates activation levels in brain regions linked to higher cognitive functions (Prakash et al., 2015)

The primary focus is on their use in catalytic cancer therapy, alongside chemotherapy, phototherapy, sonodynamic therapy, radiation, and immunotherapy

The overlaps between differentially expressed genes in each transcriptome dataset were evaluated as Venn diagrams ( and Upset plot ( RT-qPCR Total RNA was extracted from 3040 mg leaf tissues with Sepasol-RNA I Super G and the TURBO DNase free kit (Thermo Fisher Scientific) according to the manufacturers protocols, followed by reverse transcription with the PrimeScript RT reagent kit (Takara Bio, Shiga, Japan) using oligo dT primers