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Pure creatine on its own doesn't break a fast

Lancet 388, 919931

Gently massage for 3 to 5 minutes until fully absorbed

The role and therapeutic potential of melatonin in degenerative fundus diseases: diabetes retinopathy and age-related macular degeneration

It is water-insoluble, but dissolves readily in moderately polar organic solvents, such as acetone, chloroform, methylene chloride, ethyl acetate, acetonitrile, and ethanol (Berke & Shieh, 2012)