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Molecular mechanisms of metastasis The genes, which allow transformed cells to invade the surrounding tissue and attract a supportive stroma, can be defined as metastasis initiation genes and could promote cell motility, EMT, extracellular matrix degradation, bone marrow progenitor mobilization, angiogenesis or evasion of the immune system

But they're generally feeling pretty healthy

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Pre-existing autoimmune diseases and immune checkpoint inhibitors for cancer treatment: considerations about initiation, flares, immune-related adverse events, and cancer progression