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American Skullcap (Scutellaria lateriflora) The Nervous System Modulator A 2025 crossover clinical trial found skullcap improved sleep efficiency and reduced nighttime waking ( Buccato et al., 2025 )

Ketamine, a dissociative anesthetic, works along the glutamate pathway and has shown promise as a potential treatment for severe depression in small doses.80 In nootropic supplements, caffeine, cocoa, theobromine, and L-theanine may influence glutamate

It is built in the body from the amino acids lysine and methionine, and is also found in the diet mostly in red meat

In a similar manner, boswellia may help reduce the intestinal inflammation of celiac disease