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3.2.2 KEGG and GO enrichment analyses of the DEGs To elucidate the biological processes and pathways involved in hypobaric hypoxia-induced cerebral injury and the therapeutic mechanisms of oxygen interventions, we performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses on differentially expressed genes (DEGs) from each comparison group (Figure 3)

Fibroblast growth factor 21 improves diabetic cardiomyopathy by inhibiting ferroptosis via ferritin pathway

Glucose transporter GLUT1 deficiency in the endothelium was reported to worsen AD pathology in a mouse model 38

A critical paradox emerges where EPA reduces inflammation but exacerbates steatosis and hepatotoxicity under conditions of impaired mitochondrial -oxidation, indicating that a functional metabolic state is essential for its safe therapeutic use

Additional autophagy-related molecules, including RAGE, beclin, and LC-3, were found to be elevated in tumor tissues, while p62 expression was reduced