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We have shown that effective pharmacologic inhibition of GPX4 in PTC cells with direct inhibitor RSL3 induces a robust activation of ferroptosis, increased DNA damage, impaired DNA damage repair response due to reduced p-NPM1 levels, decreased cell viability and cell migration, as well as suppressed spheroid formation and viability in vitro

Given the complexity of the disease, it is therefore not surprising that dissecting cause and effect is not a simple matter

Inhaled hypertonic divalent salt aerosols, comprising calcium and/or magnesium chloride with median droplet size of 815 m, were introduced at the start of the COVID-19 pandemic 29

The substitution of the HF6 diet by standard chow without avocado oil did not correct many of these abnormalities, confirming that the removal of the HF diet is not enough to counteract NAFLD and mitochondrial dysfunction

Therefore, these antioxidants represent a potential new target for chemotherapy treatments, especially the thioredoxin reductase (TrxR) protein, which can be targeted through its selenocysteine residue