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The procedure was approval by the Ethics Committee of the Medical Science Research of Affiliated Hospital of Jining Medical University (No

In aerosolized form, MTB passes through the respiratory tract into the lungs and in most cases enters the distal alveolar cavities ( TB-specific granulomas are formed by the organized aggregation of different types of immune cells at the site of infection, in which there is a complex and dynamic interaction between MTB and the host ( When the immune function of the host is impaired, the core of the granuloma undergoes caseous changes and liquefaction in response to the accumulation of foam cells transformed from macrophages and a large number of necrotic host immune cells ( 2.1 Innate immunity in MTB infection 2.1.1 Macrophages Macrophages are an important component of TB pathogenesis, participating in early exposure to MTB and acting as a refuge for MTB during chronic infection

Its unusually high acidity, i.e., the ease with which the C-2 proton dissociates, is due to the presence of the quaternary nitrogen in the thiazolium ring, a positively charged atom capable of stabilizing the resulting carbanion by electrostatic attraction

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