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Fast feedback inhibition of the HPA axis by glucocorticoids is mediated by endocannabinoid signaling

High-dose use While trials have tested up to 1200mg/day (even as high as 2400mg/day) and illustrated safety, some report higher rates of gastrointestinal side effects, dizziness, and skin reactions at these levels.14 28 38 Additionally, these higher doses are often short-term (35 weeks) and used under clinical supervision

We apologize to those colleagues whose contributions have not been described because of space constraints

In contrast, the inhibition of HDAC1 and HDAC2 may induce widespread mRNA decay in mammalian and Drosophila melanogaster cells by enhancing protein acetylation