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[1] The formulation delivers 17-estradiol in a depot that slowly releases hormone over several weeks, thereby potentially supporting more stable serum estrogen concentrations than daily oral or transdermal preparations and potentially improving symptom control for individuals with hypoestrogenism or menopausal vasomotor instability

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A few have explicit exclusions for all weight management medications

If you are losing weight steadily at 1.0 mg with tolerable side effects, staying there is a perfectly valid strategy

A common approach is to add a volume of water that makes the math simple for future measurements