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M1 macrophages are involved in the immune response and immune monitoring through antigen presentation and the release of pro-inflammatory cytokines like IL-1 and TNF- (87)

Despite targeting both isoforms of GLS1, when CB-839 was tested against a panel of breast cancer cells, its effectiveness was limited to triple-negative breast cancer cells, which have elevated GAC expression and activity compared to receptor-positive cells (Gross et al, 2014)

Chemotherapy drugs known to cause CIPN include platinum compounds (eg, oxaliplatin, cisplatin), taxanes (eg, paclitaxel, docetaxel), vinca alkaloids (eg, vincristine, vinorelbine), the immunomodulatory agent thalidomide (Thalidomid), and the proteasome inhibitor bortezomib (Velcade) (Loprinzi, Lacchetti 2020

Drug Metab Rev 38 , 651675 (2006)

Is Phentermine a GLP-1 Medication