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Quickstart Highlights FOXO4-DRI (also known as Proxofim) is a synthetic D-retro-inverso peptide designed to selectively induce apoptosis in senescent cells by disrupting the FOXO4p53 protein interaction [1] [2]

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Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) activation occurs through both PERK and IRE1 pathways, increasing inflammatory cytokine production