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This review synthesizes the current understanding of these intricate interactions, exploring how microbiota-driven modulation of the gut and brain barriers, immune signaling, and neuronal pathways, such as those through the vagus nerve, contributes to health and disease

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The results robustly demonstrated that the synergistic combination of curcumin with complementary agents exerts pleiotropic therapeutic effects in DED, addressing multiple pathophysiological pathways simultaneously