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In summary, advancing the field of human neuroprotection demands a multidimensional recalibration, spanning conceptual clarity, more representative preclinical models, validated biomarkers, and refined clinical endpoints

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Hyaluronic acid is well-tolerated by most people, and because its naturally found in our bodies, the risk of an allergic reaction is minimal

A more recent study also used ultrasensitive single-molecule arrays to detect brain injury biomarkers in urine from patients with IS and intracerebral hemorrhage, and found that higher urine GFAP (and to a lesser extent urine NfL and t-tau) levels in patients correlated with injury burden and in-hospital death or death by 3 months (77)

Activated charcoal, 1 g/kg, should be administered every 4 hours if it can be given safely