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Strategies of deficit irrigation, when carefully optimized, have been found to improve water use efficiency without significantly lowering yield, as long as a minimum moisture level is preserved throughout the growing season 31

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Over the last three decades, several large-scale, randomized, double-blind, placebo-controlled trialsmost notably the ALADIN, SYDNEY, and NATHAN 1 trialshave cemented ALA's status as a pathogenetic support for nerve health