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Furthermore, esculetin (5 mg/kg) can inhibit the production of NO, TNF-, IL-6, iNOS and nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing in DSS-induced colitis rats by inhibiting the activation of the NF-B and MAPK signaling pathways (86,87)

The supernatant was centrifuged again at 10,000 rcf for 5 min at 4 C

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Biochemical studies have not succeeded in identifying conclusively the basis of resistance in any type of cell selected with cDDP, but they have defined several mechanisms that can contribute to resistance