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Extensive astrocyte metabolism of -aminobutyric acid (GABA) sustains glutamine synthesis in the mammalian cerebral cortex

Noppers IM, et al

Further work, utilizing 13 C-MRS, recorded a rapid increase in 13 C-glutamine enrichment early during ketamine infusion in healthy controls and patients with MDD, indicating an acute surge in prefrontal glutamateglutamine cycling 13