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We also found a negative correlation between Escherichia-Shigella enrichment and the attenuated apoptotic pathways in PSO during functional enrichment analysis, suggesting that Escherichia-Shigella enrichment is involved in attenuated apoptotic pathways in PSO patients

[PMID:25974072] Calabro KA, Harmon CM, Vali K

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The choice depends on the research model, the desired duration of action, and whether the study is focused on sustained exposure or pulsatile signaling