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Characterization of the most frequent ATP7B mutation causing Wilson disease in hepatocytes from patient induced pluripotent stem cells

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Consistently, overexpression of hHPN WT in hepsin / mice resulted in a significant increase in APAP tolerance, with survival rates exceeding 80% even after 80 h (Fig

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Whether this is due to an induction of metallothionein synthesis in the intestine to inhibit copper absorption or the copper chelating effect on intestinally presented copper remains open