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This bidirectional relationship is vital for preventing and managing conditions such as irritable bowel syndrome, highlighting the importance of peptides in gut health

Such direct inhibitory action appears surprising for a peptide thought to be primarily involved in sleep promotion

FBS fetal bovine serum Nle 1 - AnglV 100 ig/ inL 20 of Nle 1 - AnglV 100 ig/ inL D-Nle-Tyr-He-NH-(CI3 4)s-CONH 2 samples were centrifuged at 4C for 5 min at 2300x g to pellet erythrocytes, and the plasma was transferred to clean tubes