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The foundational study is Neelakantan and colleagues, 2018 , in Biochemical Pharmacology

10.1002/mnfr.202200841 98 ShakibaM.SheikhiM.PahnavarZ.TajikiA.BighamA.ForoozandehA.et al (2023)

Anti-thyroid autoantibodies are produced in addition to cell-mediated destruction, which results in antibody-dependent cell-mediated cytotoxicity

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However, the activity of p53 is positively regulated by the alternative reading frame tumor suppressor (ARF), an upstream molecule that suppresses the MDM2 activity (73)