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Although experimental structural information on DIDO SPOC is lacking, AlphaFold2 structure prediction 26,27 shows that the conserved residues cluster in patches on the domain surface similar to PHF3 SPOC (Fig

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Cooper C, Harvey NC, Bishop NJ, Kennedy S, Papageorghiou AT, Schoenmakers I, Fraser R, Gandhi SV, Carr A, D'Angelo S, Crozier SR, Moon RJ, Arden NK, Dennison EM, Godfrey KM, Inskip HM, Prentice A, Mughal MZ, Eastell R, Reid DM, Javaid MK, Group MS