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Rotating injection sites regularly helps minimize this issue

It has also shown promise in minimizing oxidative stress and supporting heart health

Biodegradation behavior of silk biomaterials, in Silk Biomaterials for Tissue Engineering and Regenerative Medicine , ed

Nat Rev Drug Discov 15 , 379380, (2016)

Interatomic contacts and hydrogen bonds were detected using the GetContacts scripts tool ( setting a hydrogen bond donor-acceptor distance of 3.3 and an angle value of 120 as geometrical cut-offs