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In addition, recent studies have shown that ghrelin administration increases the cardiac output in patients with left ventricular dysfunction without severe adverse effects, highlighting the expanded therapeutic potential of this system (Lund et al., 2023)

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IGF-1 is a strong stimulator of sebaceous lipogenesis and acne pathogenesis has been linked to elevated IIS with consecutive nuclear FoxO deficiency [16, 17]

Diagnostic value of the acid-labile subunit in acromegaly: evaluation in comparison with insulin-like growth factor (IGF) I, and IGF-binding protein-1, -2, and -3