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This key issue is absolutely required, but quite challenging, since these two dimensions correspond to traditionaly different epistemic fields

CBS degrades into tetramers and dimers Though both full-length CBS constructs resulted in highly similar filament maps, one key difference was the observed protein degradation and the presence of slightly shorter oligomers of the CBS FL construct without a permanent His-tag (Supplementary Fig

A., Welham, S., & Rose, P

Neoplasma 66 , 896907 (2019)

Abstract Although the first generation of cancer immunotherapeutics produced unprecedented improvements in clinical outcomes for individuals with cancer, novel strategies to increase treatment specificity, delivery efficiency and pharmacokinetics are still needed