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The disorder of neurotransmitter levels in PD may be one of the causes of various GI symptoms and other manifestations (Mittal et al., 2017)

10.1016/j.tcb.2023.05.003 207 PopelovO.SterbaM.HaskovP.SimnekT.HrochM.GuncovI.et al (2009)

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The sample size calculation was based on volume expansion, where 500 ml of saline is usually associated with a mean SV change of 25% (+/10%) for a mean baseline of 40 10 ml ( p- value of 0.05