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Moreover, efforts are currently being made to develop GPX4-selective covalent inhibitors with minimal toxicity and better tolerance profiles [106, 107]

Furthermore, synaptic vesicles isolated from post-mortem brain tissue from people with Parkinsons disease have decreased VMAT2 activity, suggesting that in addition to a loss in the amount of VMAT2 protein, the remaining VMAT2 additionally has decreased uptake ability (Pifl et al., 2014)