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The report highlights early metabolic studies, selected clinical trials, and certain double-blind placebo-controlled investigations that examined markers such as: blood sugar regulation insulin sensitivity cholesterol levels impaired glucose tolerance adipose tissue activity fat release and lipolytic activity While these studies generated interest in AOD-9604 as a potential anti-obesity drug candidate , the report stresses that no authority recognizes it as an active treatment for obesity, weight loss, or human use and emphasizes that it remains designated strictly for research use

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J Chem Soc Trans 119:887891 Adkins JE, Boyer EW, McCurdy CR (2011) Mitragyna speciosa , a psychoactive tree from Southeast Asia with opioid activity