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After Myers' death, Dr

Then we designed shRNA targeting the ATG10 gene, an E2-like enzyme involved in autophagy that catalyzes the conjugation of ATG12 to ATG5 ( ATG10 expression level revealed that the affinity cell sorting led to a significantly increased shRNA knockdown efficiency of 60% in the sorted cells, compared to a knockdown efficiency of 7% in the before sorting cells (Figure 5B)

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While TGF has been described to play an anti-neoplastic role in early transformation processes [57, 58], it has also been shown to play a pro-neoplastic role in many cancer types