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Therefore, in previous reports, the prognosis of these two types was examined collectively, and age, tumor diameter, and the number of vascular invasions were cited as risk factors for recurrence [141, 143-145]

These findings emphasize the fact that the cellular anti-oxidative defense system contains many compensatory mechanisms to allow survival

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However, this simultaneously allows time for hypoxic cells to reoxygenate and any remaining tumor cells to proliferate, reducing the clinical outcome of both treatments (Saggar and Tannock, 2015)