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Guo D, Yang X, Yu R, Geng J, Zhang X, Wang Y, et al

This bottom-up approach begins with enzymatic protein digestion (typically using trypsin) to generate peptides, which undergo liquid chromatographic separation before mass spectrometric analysis

10.1161/CIRCRESAHA.118.311098 127 LimC

In another study, the network analysis projected ErbB2 consistently as a central node in the HER2 subtype, interacting with proteins PI3K, SHC, and GRB2