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Functional investigations in mouse models have demonstrated that pharmacological suppression of MEK1/2, the direct upstream activator of ERK1/2, significantly attenuates airway inflammation, hyperresponsiveness, and key remodeling characteristics (Liu et al

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doi: 10.1007/s10787-020-00773-9 Summary Keywords COVID-19, SARS-CoV-2, lipid, LPC, immune, cytokine Citation Zhang S-S, Zhao Z, Zhang W-X, Wu R, Li F, Yang H, Zhang Q, Wei T-T, Xi J, Zhou Y, Wang T, Du J, Huang N, Ge Q and Lu Q-B (2024) Lipidome is a valuable tool for the severity prediction of coronavirus disease 2019

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A critical challenge stems from the mechanistic complexity of BA receptor signaling itself