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Moreover, an up-regulated TNF- protein level and decreased SYP, PSD95 and BDNF protein level was observed in the hippocampus of ethanol-exposed APP/PS1 mice, while the altered protein level was partially restored after being treated with NAC (Fig

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Changes in Synaptic Function, Bioenergetics, and Oxidative Metabolism Convergent evidence from imaging, neurochemical, and genetic studies points to disturbances in bioenergetics and mitochondrial function in the context of bipolar illness (268, 269)