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Furthermore, the role of luminal microbes in SLE development is reinforced by the fact that patients express the LTA receptor, TLR2, in greater abundance when compared to healthy controls, and the removal of commensal microbes via antibiotic treatment can ameliorate disease symptoms (Liu et al

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(2019) demonstrated that AS-IV activates the Keap1/Nrf2 antioxidant pathway by downregulating Keap1 expression in the cytoplasm, promoting dissociation of Keap1 from Nrf2, facilitating Nrf2 release and translocation to the nucleus, where it binds Maf to initiate the transcription of the antioxidant gene HO-1

9 A considerable amount of evidence suggests that glutathione depletion is an important risk factor for glaucoma

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