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Hormonal Therapies with Chemotherapy-Like Impact Although not chemotherapeutic in the classical sense, several oral hormonal agents are used as first-line systemic therapies in hormone-sensitive malignancies

However, the increase in mGluRs-dependent signaling in the mouse model of FXS was not confirmed in human-based models, and clinical trials with mGluR inhibitors failed to produce a therapeutic effect in FXS patients [331]

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440 SCFA, as the main metabolite produced by the fermentation of dietary fiber by intestinal microorganisms, can normally pass through the BBB, provide energy substrates for brain cells, and maintain mitochondrial function

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