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Public written comments can be submitted to docket FDA-2025-N-6895 through July 22, 2026

For this review, outside of these studies, unless stated otherwise, all other cuprizone research mentioned is carried out in mice

It is presented in a 100 mL (3.52 fl oz) airless jar for convenient and consistent application in research environments

4 All previous terms, including EDS type III, EDS hypermobility type, hypermobility syndrome, joint hypermobility syndrome, and benign joint hypermobility syndrome, should no longer be used

Zirngibl et al., 2022) We suspect that the high energy requirement of OLs to maintain their myelin sheaths may be one reason why they extremely susceptible to CPZ