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Plant Cell 12(3):369379 Davuluri GR, Van Tuinen A, Fraser PD, Manfredonia A, Newman R, Burgess D, Brummell DA, King SR, Palys J, Uhlig J (2005) Fruit-specific RNAi-mediated suppression of DET1 enhances carotenoid and flavonoid content in tomatoes

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2005).Taken together, these divergent findings underscore a critical and unresolved question: Can neurodegeneration proceed independently of BBB disruption, or is barrier compromise a central driver that facilitates the progression of neurodegenerative pathology