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Some topical products like hydroquinone or azelaic acid can slow down melanin production, but not as effectively or profoundly as oral tranexamic acid. And oral is the key word here: Though tranexamic acid can be used topically to slow melanin synthesis, clinical studies show it works much more effectively when taken in pill-form

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Preparation and optimisation of anionic liposomes for delivery of small peptides and cDNA to human corneal epithelial cells